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Science Summaries

The International Nutrition Company of The Netherlands (I.N.C.), the worldwide supplier of the MASQUELIER’s products, has preserved the standards and advanced the scientific research for MASQUELIER’s OPCs. The science officers at I.N.C. have produced scientific summaries, each of which provides an overview of all the science conducted on in the key health benefit category represented in the title of the summary.

   

Summary of Key Scientific Studies: Cardiovascular/Circulatory System

The beneficial effects of the phytonutrient MASQUELIER’s® OPCs on the structure and function of blood vessels (veins, arteries, capillaries and lymphatic vessels), and thereby on the circulatory and cardiovascular systems, have been indicated through sixty years of continuous scientific study, in many published peer-reviewed journal articles, and reviewed in a monograph published in Alternative Medicine Review (Oligomeric Procyanidins. Monograph, 2003).

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Summary of Key Scientific Studies: Rebuilding & Strengthening of Collagen & Elastin

Evidence from human, animal and in vitro studies strongly supports that MASQUELIER’s® OPCs can help maintain healthy skin structure and function, promote skin hydration and reduce risk of UV-induced skin damage, likely through its significant antioxidant activity and its ability to bind the essential proteins collagen and elastin, promote the synthesis and inhibit their degradation.

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Summary Of Key Scientific Studies: Antioxidant Benefits

Free radicals have gained a lot of attention in recent years because of their role in the pathogenesis of several diseases such as inflammation, atherosclerosis, arthritis, neurodegenerative conditions and cancer. Since endogenous antioxidants are frequently insufficient to protect against free radical-induced cellular damage, diet-derived antioxidants are important in maintaining health. There is sufficient epidemiological evidence correlating higher intake of certain foods or food-components rich in antioxidants with a lower incidence of various human diseases (Halliwell, 1996; Riccioni et al, 2007; Williams and Hord, 2005).

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Summary of Key Scientific Studies: Chronic Venous Insufficiency (CVI) – Leg Veins

Chronic Venous Insufficiency (CVI) is a fairly widespread disease in the Western Hemisphere. CVI is caused by abnormalities in the structure and functioning of superficial or deep veins of the lower extremities. Weakening of the vein walls and valves, decreased venous tone, phlebitis, history of varicose veins, oral contraceptives and various environmental factors (sitting or standing for long periods, age, smoking, etc.) all increase the risk of developing CVI (Eberhardt and Raffetto, 2005; Nicolaides, 2000).

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Summary of Key Scientific Studies: Benefits to Eye Health

Scientific evidence supports the potential beneficial effects of MASQUELIER’s OPCs in promoting healthy eye function in humans through improving dark adaptation and recovery from glare, as well as enhancing circulatory function and reducing vascular abnormalities in the eye, thus reducing risk of retinopathy. These observed beneficial effects of MASQUELIER’s OPCs are likely due to its ability to bind vascular wall components (eg. collagen and elastin) and strengthen the vascular wall structurally, as revealed through investigations in experimental model systems, thereby improving circulatory function that is essential to maintaining eye health.

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Summary of Key Scientific Studies: Structure, Function and Microcirculatory Abnormalities in the Eye and Beneficial Effects of MAQUELIER’s OPCs

The main function of the eye is to convert light that falls on it from the outside into electrical nerve impulses. These impulses then travel to the part of the brain responsible for vision, where they are interpreted as a visual scene. In the eye, light traverses through the tear film, cornea, anterior chamber, pupil, lens, and vitreous chamber to the retina, which sends the nerve impulses through the optic nerve to the brain. Vision is decreased if any one of these structures is abnormal, is irregularly sized, is not functioning adequately, or is not properly positioned in relation to the others.

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Masquelier’s and Flavan are registered trademarks of International Nutrition Company BV (I.N.C.), Loosdrecht, The Netherlands.