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Current Research

Learn more about the most current scientific research performed on Masquelier’s OPCs (oligomeric proanthocyanidins).

 

A Potential role for Oligomeric Proanthocyanidins (OPCs) in delaying Senescence in Endothelial cells

B. de Haan, G. Achanta* and J.A. Post

The results suggest that the specific OPCs-compound used in this study (Masquelier's Original OPCs) might delay senescence in human vascular endothelial cells, possibly by reducing DNA damage and ROS stress. The results therefore provide a basis for further investigating the potential effects of this specific OPCs-compound in reducing risk of atherosclerosis and the molecular mechanisms involved.

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Oligomeric Proanthocyanidins effectively inhibit LDL oxidation: A Mechanistic study using a lipophilic, Oxidation-sensitive, Fluorescent Probe

B. de Haan, G. Achanta*, D.van der Vlies*, J.A. Post

Atherosclerosis is a chronic inflammatory disease, and constitutes the leading cause of morbidity and mortality in the Western world. Reactive oxygen species (ROS) have been widely implicated as a causative factor in atherosclerosis. ROS promote atherosclerosis by inducing vascular endothelial cell dysfunction, oxidation of LDL, and inflammation.

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Oligomeric Proanthocyanidins Protect Vascular Endothelial Cells from Lipid Oxidation

B. de Haan, S. Bapat* and J.A. Post

Reactive oxygen species (ROS) are involved in the pathology of cardiovascular conditions such as inflammation, atherosclerosis etc. Endothelial cells, highly specialized cells, line the vasculature and thereby form a selective barrier between the circulating blood and the underlying parts of the vasculature. ROS damage to endothelial cells results in endothelial dysfunction, which plays an important role in the onset and progression of vascular disease.

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